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CBD: The Science Behind it and What You Should Know. By Our August Student Pharmacist, Christine Stearns.


Are CBD products legal?

As of July 30th, it is now legal to grow, manufacture, and sell CBD products in the state of Ohio.

Last week, Governor Mike Dewine signed Senate Bill 57, which decriminalized hemp and hemp cultivation. Prior to the bill, state laws did not differentiate between cannabis oil derived from hemp and cannabis oil derived from marijuana. This new bill will allow Ohio farmers the right to legally grow hemp, others the ability to process it, universities the ability to perform further research with it, and stores the ability to carry and sell it.

In 2018, the Farm Bill was passed, which exempted hemp and its constituents (including cannabidiol) from the Federally Controlled Substance List. However, Ohio’s previous medical marijuana law did not differentiate hemp from marijuana, and this led to confusion from retailers. This new legislation excludes hemp from the State Board of Pharmacy’s definition of marijuana with a few considerations. The product must contain less than 0.3% THC (the main psychoactive component of marijuana), and farmers who wish to grow hemp must be licensed through the Department of Agriculture beginning in 2020.


Will CBD give me a high?

Unfortunately, a lot of confusion and stigma still remain surrounding the difference between cannabinoid products.

Cannabis, or marijuana, consists of the dried leaves, stems, flowers, and seeds from the plants Cannabis Sativa and Cannabis Indica. These plants contain hundreds of compounds called cannabinoids. The most common cannabinoids include tetrahydrocannabinol (THC) and cannabidiol (CBD).

THC is the primary psychoactive chemical in cannabis, which creates the high that is associated with marijuana use.

The second chemical, CBD, does not activate the same receptors that THC does, so it does not produce any psychoactive effects in patients (even at significant doses). CBD can also be extracted from another cannabis plant called Hemp.

Hemp plants are a more fibrous variant of the Cannabis Sativa family and have been historically used in textiles and dietary supplements. Hemp plants contain less than 0.3% THC, so even at high doses, there is no high produced from the extraction. The stalks, stems, leaves, and flowers of the hemp plant naturally contain the highest concentration of CBD and are typically used to make these CBD products.

What are the benefits?

Although it is not completely clear, CBD has demonstrated some beneficial effects on receptors 5HT1a, a serotonin receptor involved in the pathways of antidepressants and anxiolytics, GPR55, a receptor that has become a new target in preventing seizures, and TRPV1, which may play a role in pain sensation.

Because of its mechanism, CBD may be beneficial in treating:

  • anxiety
  • depression
  • inflammation
  • Crohn’s Disease
  • smoking cessation
  • multiple sclerosis
  • rheumatoid arthritis
  • epilepsy
  • pain.*

These products have also shown antioxidant properties and improve mood and sleep.*

What do I need to know before trying CBD?

Before taking any CBD products, it’s important to speak with your doctor to make sure you are a candidate for the supplement. These products may not be suitable for use if you have any liver problems, are pregnant or breastfeeding, or take any of the following medications:

  • Proton pump inhibitors (omeprazole, pantoprazole, esomeprazole, etc.)
  • Benzodiazepines (alprazolam, lorazepam, clobazam, temazepam, etc.) or phenobarbital
  • Valproic acid or carbamazepine
  • Ketoconazole
  • Rifampin
  • Warfarin
  • Antidepressants
  • Narcotics

It is also important to note that just like prescription drugs, dietary supplements can produce unwanted side effects, as well.

Potential side effects of CBD products may include:

  • fatigue
  • sleep disturbances
  • lightheadedness
  • dry mouth
  • decreased appetite

The full effects of CBD products may take up to two weeks.

These products may be more readily absorbed with a meal high in fat, but can be taken with or without food.

CBD products come in many forms, but the most common ones include oils, tinctures, and capsules.

I see CBD products everywhere. Are all of these products created equally?

Because of the potential benefits demonstrated in preclinical testing and clinical trials, various CBD products have become increasingly popular products in supplement shops, whole food stores, and online. With this sudden boom in popularity, there comes a major problem. Because these products are considered dietary supplements, they are not regulated by the FDA as strictly as prescription and OTC medications. The manufacturers are not required to test what is in their products, so they may not contain the ingredients or the amounts of the ingredients that are listed on the labels. This is why it is important to do your research prior to purchase and find a CBD company that employs third party testing and has obtained a certificate of analysis on their products.

Where can I find certified CBD products?

Luckily, your local Plain City Druggist and Happy Druggist Pharmacies have identified a well-known, credible CBD company called Ananda Professional™.  Ananda is a Kentucky-based company that provides the highest quality hemp extract because they test their product at every step of their manufacturing process. Each of their products are pesticide-free, have been accredited through third party testing, and have a certificate of analysis to report the potencies of each ingredient.

We are excited to announce that we have started working with Ananda to provide our patients with safe and effective CBD products. Feel free to ask our pharmacists about CBD the next time you stop by any of our locations!

*All CBD products are considered dietary supplements, therefore, they are required to be in compliance with current good manufacturing practice (cGMP) and properly labeled. Efficacy has not been established.



  1. Pisanti S, Malfitano AM, Ciaglia E. Cannabidiol: State of the art and new challenges for therapeutic applications. Pharmacology & Therapeutics.2017;175:133-150. DOI:10.1016/j.pharmthera.2017.02.041.
  2. Wilson-Morkeh H, Al-Abdulla A, Sien L. Important drug interactions exist between cannabidiol oil and commonly prescribed drugs in rheumatology practice. Rheumatology. 2019. DOI: 10.1093/rheumatology/kez304.
  3. Corroon J, Felice J. The Endocannabinoid System and its Modulation by Cannabidiol (CBD).Alternative Therapies in Health and Medicine.2019; 25 (1078-6791):6-14. https://www-ncbi-nlm-nih-gov.proxy.lib.ohio-state.edu/pubmed/31202198. Accessed August, 6, 2019.

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